英语释义

1. the enzymatically controlled addition of a methyl group to a nucleotide base (such as cytosine in eukaryotes) in a molecule of DNA that plays a role in regulating gene expression (as by the inhibition of genetic transcription)
When a methyl group attaches to a specific spot on a gene—a process called DNA methylation—it can change the gene's expression, turning it off or on, dampening it or making it louder.
— John Cloud A handful of drugs that affect DNA methylation already exist, and are being used to treat cancers in which faulty gene labeling plays a role.
— Helen Pilcher A process called DNA methylation sets down "marks" on bits of DNA and is typically thought to squelch gene expression.
— Sarah Baldauf DNA methylation is a mark on genomic DNA made by addition of methyl groups to cytosine bases …
— Adrian Bird

2. the enzymatically controlled methylation of a nucleotide base (as cytosine in eukaryotes) in a molecule of DNA that plays a role in suppressing gene expression

片语

DNA methylation and demethylation甲基化

DNA total methylation levelDNA总体甲基化水平

DNA methylation variationDNA甲基化变化

DNA targeted methylationDNA靶向性甲基化

DNA Methylation SocietyDNA甲基化协会会员

detection of DNA methylationDNA甲基化检测分析技术

p gene dna methylationp16基因甲基化

Cytosine DNA MethylationDNA胞嘧啶甲基化

英汉例句

• sweatt「s team recently discovered that training mice to associate a certain location with a mild electric shock reduced dna methylation in the hippocampus, a brain region crucial for memory formation.

  斯维特研究小组最近发现，小鼠的电击空间关联训练降低其海马区dna甲基化，而海马区是脑部记忆形成的重要区域。

• discussing the relations of dna methylation and gene transcriptional silencing takes on important significances for the study of many human diseases.

  探讨dna甲基化与基因转录抑制之间的关系，对许多人类疾病的研究具有重要意义。

• when a methyl group attaches to a specific spot on a gene — a process called dna methylation

  甲基附加到基因上某个特殊点的过程，称为dna甲基化。

• this suggests that the presence of dna methylation in normal tissue adjacent to tumors is more prevalent that previously thought.

  这表明瘤旁组织的dna甲基化比我们原先想的要普遍。

• the work is one of several clues that dna methylation affects the formation and maintenance of memories.

  这项工作是dna甲基化影响记忆形成和延续的线索之一。

• for 5% to 10% of those genes, the dna methylation patterns, which affect how genes are expressed, are different between ivf and non-ivf children.

  这些基因中有5%到10%发生dna的甲基化形式，这就会引起两类婴儿基因表达的差别。

• we will discuss methods to address these challenges in the context of analyzing histone modifications and dna methylation data.

  我们将在分析组蛋白修饰和dna甲基化数据的背景下，讨论解决这些挑战的方法。

• an analysis of a person」s dna methylation finds that the number of methyl groups attached to the dna correlates with the person's age--making saliva analysis a possible csi tool.

  对人体dna甲基化水平进行检测发现，结合在dna上的甲基团数量与年龄有关，因此，唾沫分析技术有望成为犯罪现场取证工具。

• 「dna methylation in the kidney is different from dna methylation in the liver,」 he says.

  「肾脏内的dna甲基化不同于肝脏内的，」他说。

• dna methylation plays an important role in gene regulation and animal development.

  dna甲基化在基因调节和动物发育中起着重要作用。

• 「dna methylation in the kidney is different from dna methylation in the liver, 」 he says.

  「肾脏中的dna甲基化和肝脏中的dna甲基化是不同的」。

• they chose subjects that had come from either very high or very low standards of living, and they looked at differences in dna methylation across some 20, 000 genes.

  他们选择的对象既有生活水平非常高的也有非常低的，并且，他们覆盖了其中的20000个基因来观察dna甲基化的差异。

• abnormal dna methylation can influence the expression of certain genes, inducing occurrence and development in autoimmune diseases.

  dna甲基化异常可影响某些基因的表达，导致自身免疫性疾病的发生发展。

• the changes of epigenetics such as dna methylation and histone modification can regulate the expression of genes and play an important role in the development of tumors.

  表遗传学改变，如dna甲基化和组蛋白修饰改变可以调节基因的表达，在肿瘤的发生和发展中可能起关键作用。

• the plants were derived from two arabidopsis parents with essentially identical genomes, but with one having a mutated ddm1 dna methylation gene.

  这些植株源自两棵基因几乎相同的拟南芥，但其中一棵含有突变的ddm1甲基化dna。

• the inhibitor of dna methylation such as 5-azadeoxycytidine(5aza) can reverse this epigenetic event, suggesting that it can be used for tumor treatment.

  dna甲基化抑制剂如5氮杂脱氧胞苷（5aza）能逆转这种表观遗传学事件，说明可以用它治疗肿瘤。

• dna methylation in the promoter regions is a powerful mechanism for the suppression of gene activity.

  在启动子区域的dna甲基化是抑制基因活性的一种重要机制。

• researchers looked for - and found - a chemical change called dna methylation in healthy tissue adjacent to breast tumors.

  研究者寻找并发现了靠近肿瘤组织的健康组织中有「dna甲基化」这种化学改变。