英语释义

1. a hydrolytic enzyme that occurs on the surface of the pneumococcus, influenza-causing viruses, and some paramyxoviruses as an antigen and that splits mucoproteins by breaking a glucoside link

2. a hydrolytic enzyme that occurs on the surface of the pneumococcus, the orthomyxoviruses, and some paramyxoviruses and that cleaves terminal acetylated neuraminic acids from sugar residues (as in glycoproteins and mucoproteins)

片语

neuraminidase inhibitors神经氨酸酶抑制剂

neuraminidase gene神经氨酸酶基因

NA neuraminidase神经氨酸酶

neuraminidase 2目的研究细胞质唾液酸酶

Neuraminidase InhibitorNeuraminidase inhibitors are a class of antiviral drugs targeted at the influenza virus, which work by blocking the function of the viral neuraminidase protein, thus preventing the virus from reproducing by budding from the host cell.

Neuraminidase NA神经氨酸酶

N1 neuraminidaseN1神经氨酸酶

neuraminidase assay神经氨酸酶测定

英汉例句

• it codes for the neuraminidase enzyme — the n1 in h1n1 — which controls the expansion of the virus from infected cells.

  因为其指定的神经氨酸酶遗传密码——h1n1中的n1——控制着被感染细胞的病毒扩散。

• for the neuraminidase inhibitors, the main constraints – which are substantial – involve limited production capacity and a price that is prohibitively high for many countries.

  就神经氨酸酶抑制剂而言，有一些重大的限制因素，主要是生产能力有限，同时，在许多国家，其价格高得难以负担。

• neuraminidase plays an important role in the pathogenicity of influenza infections.

  神经氨酸酶在流感病毒的感染和传播过程中起着重要作用。

• the virus that was currently detected in the us and mexico is susceptible to neuraminidase inhibitors but resistant to amantadanes.

  但是，近期在美国和墨西哥发现的病毒对抑制剂很敏感，却对amantadanes有抵抗力。

• to overcome drug resistance, researchers are searching for alternative sites on neuraminidase against which new drugs can be targeted.

  为了克服耐药性，科学家正在神经氨酸酶上寻找一个替代的位置，并针对其开发新药。

• the h5n1 virus is expected to be susceptible to the neuraminidase inhibitors.

  h5n1病毒预期对神经氨酸酶抑制剂敏感。

• simultaneously, physician should pay attention to the resistance of neuraminidase inhibitor.

  同时提醒关注神经氨酸酶抑制剂应用的耐药问题。

• furthermore, protease inhibitors of viral entry could be potentially useful against influenza virus as well as neuraminidase inhibitor-resistant viruses.

  此外，加工蛋白酶抑制剂可以用于神经氨酸酶抑剂抵抗的病毒感染时。

• rats received two intravenous injections of either heparinase iii to digest hs or neuraminidase to remove neuraminic acids.

  实验大鼠接受两次肝素酶iii注射以消化hs，或两次神经氨酸酶注射以除去神经氨酸。

• the viruses showed no mutations associated with resistance to the neuraminidase inhibitors, including oseltamivir (tamiflu).

  这些病毒显示没有与包括奥斯他韦（达菲）在内的神经氨酶抑制剂耐药性有关的突变。

• the next big target is another surface protein, neuraminidase (see 「moving target」).

  其次是另一种表面蛋白神经氨酸酶（见 「转移攻击 」 ）。

• the acting mechanism and structure-activity relationship of each kind of influenza neuraminidase inhibitors with dissimilar structures were reviewed.

  根据化学结构的不同，综述各类神经氨酸酶抑制剂的作用机制及构效关系。

• neuraminidase (na) is an important protein on the surface of virion and plays an important role in immune and lethality.

  神经氨酸酶（na）是流感病毒表面的一种重要蛋白质，在免疫和致病方面起重要作用。

• two main classes of drug interfere with influenza virus infection which are used for prevention and treatment in clinic are the m2 ion channel blocker and the viral neuraminidase inhibitors.

  目前，在临床上预防和治疗流感的药物主要有m2离子通道抑制剂、神经氨酸酶抑制剂两类。

• there are two classes of such medicines, 1) adamantanes (amantadine and remantadine), and 2) inhibitors of influenza neuraminidase (oseltamivir and zanamivir).

  这种药物有两类：1）烷胺类药物（金刚烷胺和金刚乙胺），2）流感的神经氨酸酶抑制剂（奥司他韦和扎那米韦）。

• objective: to select the peptide binding to influenza virus neuraminidase from phage display 12 peptide library.

  目的：从噬菌体呈现12肽库中筛选与流感病毒神经氨酸酶特异性结合的肽。

• after the virus infects the cells of the respiratory system and begins replicating, neuraminidase cuts the newly formed copies free to invade other cells.

  呼吸系统内的细胞染上病毒，而且病毒开始复制之后，神经氨酸酵素会将新生的病毒切下以便侵犯其他细胞。

• both of these agents are neuraminidase inhibitors with activity against both influenza a and b viruses.

  这两种药嗾使神经氨酶抑制剂，能抵抗流感a、b病毒。

• zanamivir and oseltamivir bind differently at the neuraminidase catalytic site and this contributes to different drug resistance profiles.

  扎那米韦和奥塞米韦结合在神经氨酸酶的不同催化位点，这就导致了这种耐药情况不同的发生。

• the efficacy of the neuraminidase inhibitors depends, among others, on their early administration ( within 48 hours after symptom onset).

  神经氨酸酶抑制剂的疗效特别取决于其早期使用（在癥状出现后48小时之内）。

• antiviral resistance to neuraminidase inhibitors has been clinically negligible so far but is likely to be detected during widespread use during a pandemic.

  到目前为止，对神经氨酸酶抑制剂的抗病毒制剂耐药性，在临床上很微弱，但在大流行期间广泛使用这类抑制剂时可能会出现。