aripiprazole in overall yield of 68% was synthesized from 2,3-dichloroaniline by a three-step nucleophilic substitution reaction in yield of 83%, 91% and 90%, respectively.
以2,3-二氯苯胺为原料,经3步亲核取代反应合成了阿立哌唑。3步反应的收率分别为83%,91%和90%;总收率68%。
the rule and the feature for aromatic nucleophilic substitution reaction were studied based on the relationship between its structure and activity. the electronic effect on the reaction was discussed.
以结构与活性关系为主线,深入研究了芳香亲核取代反应的规律和特点以及反应中的电子效应的作用及其影响。
two derivative dyes from the parent dyes were obtained by nucleophilic substitution reaction in which two primary aminophenol were employed as the nucleophilic reagent.
将母体染料的中位氯原子用氨基酸试剂亲核取代,衍生合成了两个中位氨基酸取代的七甲川菁染料。
five derivative dyes from the parent dyes were obtained by similar nucleophilic substitution reaction in which five primary amines were employed as the nucleophilic reagent.
将母体染料的中位氯原子用氨基试剂亲核取代,衍生合成了五个中位仲胺七甲川菁染料。
at the same time , discuss about the impact factor to nucleophilicity such as the number of attract electron group, ability of attract electron and the nucleophilic substitution reaction part.
并且对亲核试剂的体积效应、溶剂效应对亲核性影响,底物上吸电子基团的数目、吸电子能力对亲电性的影响,以及亲核取代反应的发生部位受哪些因素影响进行探讨。