The natural product thiostrepton is known to reduce the transcriptional activity of FOXM1, a transcription factor involved in tumorigenesis and cancer progression.
已知天然产物硫链丝菌肽降低涉及到肿瘤发生和癌癥发展的一个转录因子FOXM1的转录活性。
Herein we demonstrate that thiostrepton interacts directly with FOXM1 protein in the human breast cancer cells MCF-7.