To assess the clonal origin of renal clear cell carcinomas by the study of X-chromosome inactivation pattern in female clear cell renal carcinomas and normal renal tissues.
本实验将通过研究女性肾透明细胞癌及正常肾组织的X染色体失活类型判断肾透明细胞癌克隆起源。
This phenomenon is mostly seen in imprinted genes and X-chromosome inactivation where DNA methylation of promoter regions leads to repression of gene expression.