英语释义

1. a mechanism in which different combinations of exons are joined together during the final stages of transcription so that more than one messenger RNA is produced from a single gene
In complex genes, alternative splicing can generate dozens or even hundreds of different mRNA isoforms from a single transcript.
— Vivien Marx, Genomics & Proteomics, May 2004 — called also differential splicing Note: Alternative splicing produces different messenger RNAs especially through the removal of one or more exons. Since each messenger RNA produced forms a different protein product, this mechanism enables a gene to encode multiple proteins that are structurally and functionally distinct.

片语

alternative splicing isoform剪接异构体

alternative RNA splicing剪接

cell specific alternative splicing细胞特异的选择性剪接

Alternative Splicing and Disease选择性拼接与疾病

alternative splicing variants选择性剪接变异体

alternative mrna splicing可变RNA剪接

repressive alternative splicing阻遏性选择剪接

alternative splicing variants gene选择性剪接变异体

Alternative Splicing Database选择性剪接数据库

英汉例句

• on transcriptional level, no foregone alternative splicing event was found.

  在转录水平，发现了新的异常剪接基因。

• this work demonstrate a molecular mechanism for the creation of novel proteins through alternative splicing in the central nervous system during human evolution.

  本项研究表明，在人类起源中，基因剪切的变化可能是导致人脑中产生新的蛋白质进而出现新功能的重要机制之一。

• alternative splicing is often regulated in tissue-and developmental stage-specific manner, or in response to extracellular stimuli.

  可变剪接具有高度的组织与发育阶段特异性，并受到外界信号的控制。

• alternative splicing (as) is a key process underlying the expansion of proteomic diversity and the regulation of gene expression.

  选择性剪接是扩大蛋白多样性和调节基因表达的重要过程。

• notable differences were identified between the predicted three-dimensional structure of the normal epsps edna sequence and the alternative splicing sequence.

  该可变剪接序列预测的三维结构模型同正常的epsps基因的三维结构存在显着差异。

• alternative splicing of pre-messenger rna is a key feature of transcriptome expansion in eukaryotic cells, yet its regulation is poorly understood.

  信使rna前体可变剪接是真核细胞转录的一个主要特点，但其调控知之甚少。

• cd72 is a b cell specific receptor that exists in multiple alternative splicing forms.

  cd72是一个重要的b细胞特异性受体，它以多种选择性剪切形式存在。

• 「we found that the regulation of alternative splicing is different in mesenchymal versus epithelial cells, 」 garcia-blanco said.

  我们在对间充质性细胞与上皮性细胞的比较中发现，选择剪切的规律是不一样的。

• alternative splicing plays an important role in processes such as development, differentiation and cancer.

  可变剪接在发育、分化和癌癥等过程中发挥着非常重要的作用。

• alternative splicing is generally believed to occur more than 50% of actively transcribed human genes and thus is highly relevant to disease and therapy.

  人类的基因中，超过50%的转录产物进行选择性剪接，而这机制和疾病发生、治疗方法有高度的相关性。

• alternative splicing didn't help either: it could be argued that it represents a case of rna making itself, then making a bunch of different proteins.

  选择性拼接也不肯帮忙：它可以被看作另外一种例外——rna还能自我复制，然后制造出一揽子形形色色的蛋白质。

• spliced alignment is a sequence alignment method which considers the different alternative splicing forms during alignment.

  剪接比对指的是在比对过程中考虑不同选择性剪接方式的序列比对方法。

• the riboswitches play important roles in translation initiation and alternative splicing by switching between two mutually exclusive structures .

  核糖开关通过结合特定代谢分子在2种结构状态下切换，调控可变剪接和翻译起始。

• it is possible for molecular therapy to target directly isoforms of protein produced by alternative splicing or to interfere with the process of alternative splicing.

  以选择性剪接蛋白异构体为靶点或干预选择性剪接过程，可望进行肿瘤的分子治疗。

• studying alternative splicing mechanism is of great significance to understanding eukaryote gene regulation.

  研究基因的可变剪接对理解真核生物基因调控具有十分重要的意义。

• a heuristic algorithm for multiple alignment was developed to more effectively study alternative splicing patterns of eukaryotic genes.

  为对真核基因的选择性剪接形式进行準确、快速、有效的研究，提出了一种启发式多序列比对算法。

• in recent years, more and more researches showed that alternative splicing was highly relevant to cancer, and many cancer genes were regulated by alternative splicing.

  近年来，越来越多的研究表明可变剪接与癌癥有着密切的关系，许多癌癥相关基因受可变剪接调控。