英语释义

• a simple protein containing mainly basic amino acids; present in cell nuclei in association with nucleic acids

片语

histone repression组蛋白阻遏

histone variant组蛋白变体

Histone H2BHistone H2B is one of the 5 main histone proteins involved in the structure of chromatin in eukaryotic cell Featuring a main globular domain and a long N terminal tail H2B is involved with the structure of the nucleosomes of the 'beads on a string' structure.

histone cistron组蛋白顺反子

histone octamer[遗] 组蛋白八聚体

Histone Deacetylases组蛋白脱乙酰基酶类

histone geneA histone gene is a gene that codes for histone protein

英汉例句

• the changes of epigenetics such as dna methylation and histone modification can regulate the expression of genes and play an important role in the development of tumors.

  表遗传学改变，如dna甲基化和组蛋白修饰改变可以调节基因的表达，在肿瘤的发生和发展中可能起关键作用。

• in the histone code the methylation target is known as h3k9, where k stands for lysine.

  这一组蛋白的甲基化靶点就称为h3k9，其中k代表赖氨酸。

• dr. fischer’s research shows that when young mice are learning, an acetyl group binds to a particular point on the histone protein.

  费舍尔博士的研究显示，当一只年轻的白鼠在学习时，一个乙酰基群在组蛋白上抱成特殊的节点。

• as in the alzheimer「s mice, drugs that boosted histone acetylation improved the older mice」s performance on tests of rodent cognition.

  如同阿尔茨海默病鼠，增强组蛋白乙酰化的药物改善了年老小鼠在认知测试中的表现。

• scientists also suspect that the compounds responsible for this insight, called histone deacetylase inhibitors, could significantly slow memory loss—perhaps for years.

  他们怀疑这种复合物控制着人类的洞察力，这种复合物称为蛋白脱乙酰基酶抑制物，能够明显减轻记忆遗失——作用可能长达几年之久。

• core processes of epigenetic inheritance include dna methylation, histone modification, nucleosome remodeling, nuclear dynamics and chromatin interaction with non-coding rnas.

  核心过程的表观遗传的产业包括dna甲基化、组蛋白改性、核小体重建、核染色质动力学和互动子都存在。

• the histone code will not be easy to crack.

  组织蛋白的密码不是那么容易破解的。

• satb1 also globally regulates histone status in the chromatin by recruiting histone-modifying enzymes to the target-gene loci.

  在染色体中，satb1还在靶基因位置上通过复活组蛋白修饰酶普遍的调节组蛋白的状态。

• more recently, fischer, who is now at the european neuroscience institute in g?ttingen, germany, has been investigating alterations in histone acetylation that occur naturally with age.

  最近，菲舍尔在德国格廷根的欧洲神经科学研究所，研究组蛋白乙酰化中随衰老发生的自然改变。

• we will discuss methods to address these challenges in the context of analyzing histone modifications and dna methylation data.

  我们将在分析组蛋白修饰和dna甲基化数据的背景下，讨论解决这些挑战的方法。

• a group of proteins called the polycomb repressive complex 1 (prc1) that silences genes must first bind to a particular methylated address on a histone and.

  一组称为多梳抑制复合物1（prc1）蛋白质沉默基因必须先结合到特定的组蛋白上的甲基化位点。

• a small molecule called an acetyl group attaches to a particular histone known as h4.

  一个小小的分子称作一个乙酰基团，它黏在一个称作h4的特殊组蛋白上。

• histones are proteins that regulate dna packing, and histone deacetylases are enzymes that control the way those proteins work.

  组蛋白控制dna折叠，而组蛋白去乙酰酶抑制剂是种控制这些蛋白质工作的酶。

• it ensures that the h4 histones have plenty of attached acetyl groups, so the dna wrapped around the histone once again becomes available for transcription.

  它保证了h4组蛋白有大量的乙酰基团粘附其上，所以环绕在组蛋白上的dna能再次被翻译。

• to reverse the memory loss, doctors inject a compound called a histone deacetylase inhibitor.

  为了逆转记忆遗失，医生在复合物中添加了组蛋白脱乙酰基酶抑制物。

• dna remains tightly wound around the histone spool, so the genes on the spool that control memory formation remain suppressed.

  病态的dna仍紧紧的环绕在蛋白质纺锤体上，因此在纺锤体上控制记忆合成的基因没有被激活，即受到了抑制。

• other work has focused on histone acetylation, a chemical modification that unwinds dna from protein spools called histones, thereby enabling gene activity.

  其他的工作集中在组蛋白乙酰化，这种化学修饰可以使dna从组蛋白缠绕中解离出来，产生基因活性。

• histone h4 is one of five histone groups.

  h4组蛋白就是五个组蛋白团之一。

• histone proteins both protect dna and regulate genes as they combine with dna to form chromatin.

  组蛋白既保护dna也在它们与dna结合形成染色质时调节基因表达。

• here, we report the patterns derived from the analysis of 39 histone modifications in human cd4 t cells.

  这里，我们报告了来自于人类cd4细胞中39个组蛋白修饰的分析的模式。

• in addition to the mhc, this region on chromosome 6 also contains a cluster of histone genes.

  除了mhc外，6号染色体上的该区域也包含一组组蛋白基因。

• the methylation of histone h3-k27 was proved to be linked to several silencing phenomena including homeotic-gene silencing, x inactivation and genomic imprinting.

  组蛋白h3第27位赖氨酸的甲基化与同源盒基因沉默、x染色体失活、基因印记等基因沉默现象有关；

• with this methyl-group mimic in hand, his team could then synthesize purified histones with methyl groups inserted at any desired point on the histone structure.

  利用这种甲基基团的仿制品，他的小组可以合成任何一点携带甲基基团的纯组蛋白。

• genes can also be silenced by modification of the histone proteins that make up the 「smart stuffing」 in chromosomes.

  基因也可以通过组蛋白的修饰被沉默，组蛋白是组装染色体的「填料」。

• here’s a video that animates the acetylation of histone proteins in the regulation of gene expression in cancer cells

  下面的视频是关于在癌癥细胞里的常规基因表达是如何进行组蛋白乙酰化作用（acetylationofhistone ）的。

• the enzymes in question are histone acetyltransferase (which adds acetyl groups to proteins) and methylated dna-binding protein-2 (which removes methyl groups from dna).

  这两种酶是组蛋白乙酰转移酶（它能给蛋白质添加乙酰基）和甲基化dna结合蛋白-2（它能把dna上的甲基去除）。