histone acetylation has a close relation with some biological effects such as gene transcription, and is catalyzed by histone acetyltransferases.
组蛋白乙酰化与基因转录等生物效应有密切的关系,组蛋白乙酰化主要是由组蛋白乙酸转移酶催化的。
conclusion app expression on sh-sy5y cells may increase through up-regulation of histone acetylation through p38mapk pathway.
结论p38mapk信号通路可能通过上调组蛋白乙酰化水平增加sh-sy5y的app蛋白表达。
the modification for histone acetylation is of great importance for formulation and development of tumors in the epigenetic study of tumors.
在肿瘤的表观遗传学研究中,组蛋白的乙酰化修饰对肿瘤的发生发展起重要作用。
more recently, fischer, who is now at the european neuroscience institute in g?ttingen, germany, has been investigating alterations in histone acetylation that occur naturally with age.
最近,菲舍尔在德国格廷根的欧洲神经科学研究所,研究组蛋白乙酰化中随衰老发生的自然改变。
histone acetylation and de-acetylation can change the structure of chromatin, involving in gene expression regulation and nuclear reprogramming.
组蛋白乙酰化和去乙酰化可以改变染色质的结构,参与基因的表达调控和重编程。
epigenetic modification such as histone acetylation plays a key role in occurrence and development of cervical cancer.
组蛋白乙酰化等表观遗传修饰在宫颈癌的发生及发展中具有重要作用。
purpose to investigate the effects of dna methylation and histone acetylation on the expression of tumor associated genes and cell cycle progression in human colonic cancer cells.
目的观察dna甲基化和组蛋白乙酰化对人结肠癌细胞系癌相关基因的表达和细胞周期的影响。
as in the alzheimer「s mice, drugs that boosted histone acetylation improved the older mice」s performance on tests of rodent cognition.
如同阿尔茨海默病鼠,增强组蛋白乙酰化的药物改善了年老小鼠在认知测试中的表现。
in this thesis, we studied the mechanisms of histone acetylation in cell cycle regulation in physarum polycephalum, a naturally synchronized slime mold.
本文以多头绒泡菌为实验材料,利用其天然同步化的优点,从新的角度研究了组蛋白乙酰化修饰对真核细胞周期调控的作用机制。
the level of histone acetylation plays an important role in progression, proliferation and differentiation of leukemia.
组蛋白乙酰化水平的异常在白血病的发展、增殖和分化中起着很重要的作用。
the chromatin remodeling and histone acetylation were associated with transcription activation.
真核基因活化与染色质的重建及组蛋白的乙酰化相关。
in the 10 may 2007 issue of nature, they reported that a drug that promotes histone acetylation improved learning and memory in a mouse model of alzheimer's disease.
在2007年5月10日的自然杂志中,他们报道了一种促进组蛋白乙酰化的药物,它能增强阿耳茨海默氏病模型老鼠的学习和记忆能力。
hdac and histone deacetylase inhibitors (hdi) can affect expression of some specific genes and induce cell differentiation growth arrest and apoptosis through regulating histone acetylation level.
组蛋白脱乙酰基酶与组蛋白脱乙酰基酶抑制剂通过对组蛋白乙酰化水平的调控,影响特定基因的表达,改变细胞周期的进程。
combined with the results of histone deactylase inhibitor, it is suggested that histone acetylation plays an important role in hsp gene transcription regulation.
结合以上去乙酞化酶抑制剂的实验结果,我们认为组蛋白乙酞化修饰参与了热休克基因的表达调控。