英语释义

1. a salt or ester of valproic acid especially sodium valproate

片语

Valproate SemisodiumValproate semisodium (INN) or divalproex sodium (USAN) consists of a compound of sodium valproate and valproic acid in a 1:1 molar relationship in an enteric coated form. It is used in the United Kingdom, Canada, and United States for the treatment of the manic episodes of bipolar disorder.

Sodiun valproate丙戊酸钠

Valproate Pivoxil丙戊匹酯

lamotrigine valproate拉莫三嗪

Calcium valproate丙戊酸钙

Semisodium valproate丙戊酸半钠

Sodilum Valproate丙戊酸钠

intravenous valproate静脉注射丙戊酸

英汉例句

• Objective: to assess the efficacy of sodium valproate XR (Depakine) in the supplementary therapy of excitement state in patients with schizophrenia and schizoaffective disorder.

  目的：评价丙戊酸钠缓释剂辅助治疗兴奋躁动的精神分裂癥以及分裂情感障碍的疗效。

• Objective To observe the effect of magnesium valproate sustained release tablets on children with epilepsy and its effects on cognitive function.

  目的观察丙戊酸镁缓释剂治疗癫的疗效及其对癫患儿认知功能的影响。

• That valproate exposure carries a higher risk of birth defectsthan other antiepileptics, such as lamotrigine and carbamazepine, is not new knowledge, Torbjorn Tomson, M.D.

  暴露在丙戊酸钠下具有比其他抗癫痫药更高的出生缺陷，比如卡马西平和拉莫三秦。

• Neither sodium valproate nor Verapamil showed any effect on action potential amplitude, overshoot, resting potential and phase o upstroke velocity.

  丙戊酸钠和异搏定对动作电位幅度、超射值、静息电位、O期最大除极速度均无明显影响。

• Methods To analyze the data of monotherapy with retard tablets of magnesium valproate in 86 cases of differentepileprtic seizure.

  方法对86例应用丙戊酸镁缓释片治疗癫痫的患者资料进行回顾性分析。

• Objective:To determine the serum levels of sodium valproate delayed - release tablets after oral administration and to evaluate in vivo and in vitro correlation by Wanger - Nelson method.

  目的：测定自制丙戊酸钠缓释片的体内血药浓度，通过丙戊酸钠缓释片的体外释放度实验，利用统计学方法研究其体内外参数的相关性。

• CONCLUSION: in therapeutic drug monitoring of valproate, it should be concerned about the impact factors of valproate concentration to ensure the safety and efficacy in patients.

  结论：在丙戊酸治疗药物监测中，要关注影响丙戊酸血药浓度的因素，确保患者用药安全有效。

• No effects of risperidone on lithium or valproate exposure were observed, despite a 20% increase in valproate peak plasma concentration.

  我们没有观察到利培酮合用锂盐或丙戊酸钠的不良反应，尽管在丙戊酸钠上血浆浓度峰值增加20%。

• Objective: Antiepileptic drugs (AEDS) may affect serum thyroid hormone concentration. this study aimed to evaluate thyroid function in men taking carbamazepine (CBZ), or valproate (VPA) for epilepsy.

  目的抗癫痫药物可以引起甲状腺激素水平改变，本研究旨在探讨抗癫痫药卡马西平(CBZ)、丙戊酸钠(VPA)对男性癫痫病人甲状腺激素水平的影响。

• Objective: to investigate the therapeutic effect of sodium valproate on gilles DE la tourette syndrome.

  目的探讨丙戊酸钠治疗多发性抽动秽语综合癥的疗效及安全性。

• Objective To investigate the clinical efficacy and side effects of sodium valproate in the treatment of alcohol withdrawal reaction.

  目的探讨丙戊酸钠对酒精戒断反应的临床疗效及副反应。

• Conclusion: Lower dose sodium valproate is effective in the treatment of TD caused by antipsychotics. Close attention should be paid to the platelet count.

  结论：丙戊酸钠治疗抗精神病药所致TD有效，但以低剂量为宜，应注意监测血象。

• CONCLUSION: This HPLC-fluorescence method is quick, sensitive and economical, which can be used to monitor the concentration of sodium valproate in human serum.

  结论：本检测方法快速、灵敏、经济，可用于监测人血清中丙戊酸钠的浓度。

• The risk of developing a rash is higher if taking lamotrigine while also taking valproate or divalproex sodium or if taking a higher starting dose or increasing the dose faster than prescribed.

  如果使用拉莫三嗪的同时使用了丙戊酸钠或双丙戊酸钠，或者采用了更高的起始剂量，或是增加剂量速度过快都有可能增加发生皮疹的风险。

• AIM: To observe the effects of sodium valproate in the repair of rat sciatic nerve injury through the drug experiment of the model of sciatic nerve injury.

  目的：通过对坐骨神经损伤模型的药物实验研究，观察丙戊酸钠对大鼠周围神经损伤的修复作用。

• Objetive the aim of this paper was to observe the clinical efficacy of valproate magnesium in mania.

  目的探讨丙戊酸镁抗躁狂癥的临床疗效。

• All rats were randomly divided into six groups: KXZZ high-does group, KXZZ middle-does group, KXZZ low-does group, valproate magnesium group, model group and normal control group.

  实验大鼠随机分为中药高剂量组、中药中剂量组、中药低剂量组、丙戊酸镁组、模型组、正常对照组。 观察各组大鼠的惊厥潜伏期；

• OBJECTIVE to explore the pathogenesis of thrombocytopenic purpura caused by sodium valproate treatment.

  目的探讨丙戊酸钠致血小板减少性紫癜可能发生机制。

• Objective: to evaluate the efficacy and side effects of sodium valproate and carbamazepine in the treatment of manic episodes refractory to lithium carbonate.

  目的：评价丙戊酸钠与卡马西平对锂盐治疗无效的躁狂发作的疗效和副反应。

• Children and adolescents with bipolar disorder generally are treated with lithium, but valproate and carbamazepine also are used.

  儿童和青少年患者常使用锂盐治疗，但也使用丙戌酸钠和卡马西平。

• Objective: to compared the pharmacokinetics of sodium valproate suppository with sodium valproate tablets.

  目的：比较丙戊酸钠栓剂与片剂的药代动力学特征。

• ABSTRACT Objective: To study the influence of sodium valproate on plasma fibrinogen.

  目的：研究丙戊酸钠对血浆纤维蛋白原的影响。

• In the present article, the mechanism of action and adverse effects of valproate sodium and the improvement of its dosage form are reviewed.

  本文对丙戊酸钠在癫痫治疗中的应用、作用机理、毒副作用以及丙戊酸钠的剂型发展作一介绍。

• METHODS: the serum concentrations of valproate in 276 patients were determined by fluorescence polarization immunoassay and the results were analyzed.

  方法：采用荧光偏振免疫法测定276例癫痫患者的丙戊酸血药浓度并分析结果。

• OBJECTIVE: To prepare sustained-release magnesium valproate tablet (test drug) and evaluate its in vitro drug release property and bioequivalence in human.

  目的：研制丙戊酸镁缓释片，并评价其体外释药特性及体内生物等效性。

• As a first - line agent for treating epilepsy, valproate sodium is widely used in clinic.

  丙戊酸钠作为常用一线抗癫痫药，目前在临床的应用较为广泛。