A new review summarized published adverse effects when IV lipid emulsion is used along with venous-arterial extracorporeal membrane oxygenation (VA-ECMO) in patients with cardiotoxic drug poisoning.
Mismatches between myocardial fatty acid uptake and utilization lead to the accumulation of cardiotoxic lipid species, and cause lipotoxic cardiomyopathy.
心肌游离脂肪酸的摄入和利用的失协调导致心肌中脂质积聚并进而引起脂毒性心肌病。
Duloxetine appears to be less cardiotoxic and is licensed in the US and EU for alleiating DPN.