thus, the neu-induced primary chromosome breakage may not be repaired by the ligase.
由neu所诱发的染色体初级断裂不能为连接酶所修复。
rearrangement --- chromosome breakage followed by reconstitution in an abnormal combination. if unbalanced, the rearrangement can produce an abnormal phenotype.
染色体结构改变造成遗传物质的重新排列。若为非平衡型重排,则可导致异常表型。
「when dna at telomeres is repaired chromosomes fuse together. if these cells then divide you could get chromosome breakage and genome instability, which leads to cancer, 」 explains karlseder.
it showed very significant difference in the rate of micronucleus and frequency of chromosome breakage between the adding medicine groups and the control group (p0. 01).