entrapment efficiency
包封率
2025-10-31 12:02 浏览次数 10
包封率
objective to establish a method for determining carboplatin content and entrapment efficiency of thermo-sensitive liposomes and to study temperature-sensitive release property in vitro.
目的建立卡铂热敏脂质体包封率和含量测定方法,并对其体外热敏释药特性进行考察。
conclution the method is convenient, accurate and suitable for determining the content and entrapment efficiency of carboplatin liposome. liposomes of carboplatin are temperature-sensitive remarkably.
结论本方法简便、準确,可以用于测定卡铂脂质体的含量和包封率,所制得的热敏脂质体具有显着的热敏释药特性。
methods the effect of cholesterol content, lipid-drug ratio, incubation time and temperature, and calcium acetate concentration on entrapment efficiency was studied.
方法以包封率为指标,考察阿魏酸脂质体胆固醇含量、脂药比、孵育时间、孵育温度、钙离子浓度等因素对包封率的影响。
conclusion: the hcpt-ssln has high entrapment efficiency and drug loading, uniform particle size, good stability, which initially indicates that hcpt is fit for being incorporated into ssln.
结论:本实验制备的hcpt-ssln包封率和载药量较高,粒径分布均匀,稳定性良好。初步表明hcpt适合进行ssln包裹。
conclusion the method is convenient, accurate and suitable for determining the content and entrapment efficiency of carboplatin liposomes. carboplatin liposomes are temperature-sensitive remarkably.
结论本方法简便、準确,可以用于测定卡铂脂质体的含量和包封率,所制备的热敏脂质体具有显着的热敏释药特性。
it also describes the quality of the evaluation of liposome several indicators, such as shape, size, entrapment efficiency stability, detection methods at home and abroad.
另外还介绍了评价脂质体质量的几个指标,如形状大小、包封率、稳定性检测方法的国内外研究进展。
the liposomes and free drug were separated by sephadex filtration, dialysis and refrigerated ultracentrifugation, respectively, then the entrapment efficiency of the liposomes was calculated.
分别采用葡聚糖凝胶过滤法、透析法、超速冷冻离心法分离脂质体和游离药物,计算脂质体包封率。
the drug-loading coefficient and entrapment efficiency of itz in micelles were investigated by hplc. results:.
动态光散射法测定胶束粒径,hplc 法测定胶束的载药量和包封率。
aim to prepare clarithromycin floating beads and investigate its buoyancy, entrapment efficiency and drug release behavior in vitro.
目的制备克拉霉素胃漂浮小丸,考察其漂浮性,包封率和体外释药行为。
resultsthe entrapment efficiency with passive loading method was low, while up to 84.38% with active loading method.
结果被动载药法制备脂质体包封率较低,主动载药制备脂质体包封率为84.38%。
objectiveto prepare and determine the content and entrapment efficiency of hydroquinone liposome.
目的制备氢醌脂质体并测定含量及包封率。
results the entrapment efficiency of zto was greater than the curcumol, but the yield efficiency of zto was less then the curcumol clearly in the liposomes containing zto.
结果莪术油脂质体中莪术油的包封率大于莪术醇的包封率,但产率明显小于莪术醇的产率;
the stability of l-hcpt was valuated with the indexes of appearance, diameter, entrapment efficiency and preoxidation value in 4. 25 . 40 for 3 month.
将脂质体于4、25、40℃条件下避光密闭放置3个月,对其外观、粒径大小、包封率和过氧化值进行考察,评价脂质体制剂的稳定性。
conclusion: this method is convenient and accurate for determining the entrapment efficiency and content of op-nlc.
结论:超滤法操作简便、準确,可以用于op-nlc含量和包封率的测定。
conclusion the results suggest that the conditions and technology are practical to prepare the liposomes containing entrapped cyclodextrin complex with high entrapment efficiency and stability.
结论实验结果提示,该制备工艺和处方可用于制备具有较高包封率及稳定性的桂利嗪包合物脂质体。
methods liposme was prepared with different method, using entrapment efficiency as the optimized indexes.
方法以包封率为主要指标,对不同制备方法进行考察。
after adoptingoptimized preparation formulation, thymosin entrapment efficiency of 89.7% was achieved.
通过优化制备工艺参数,药物包封率可达89.7%。
objective: to improve the oral bioavailability of progesterone, a new kind of oral proliposome was prepared, and the entrapment efficiency of progesterone proliposome was determined.
目的:为了提高口服黄体酮后的生物利用度,开发黄体酮口服制剂,制备了一种新型黄体酮前体脂质体口服制剂,并测定了其水合后的包封率。
results the entrapment efficiency with passive loading was only 13.3%; while up to 84.6% with active loading method.
结果被动载药法得到的包封率仅有13.3% ,主动载药法的包封率最高可达84.6 %。
the average entrapment efficiency of insulin was 72.66% determined by radioimmunoassay.
放射免疫法测得的药物包封率为72.66%。
results free drugs could be effectively separated from the hup asln by ultrafiltration. the average entrapment efficiency of three batches of hup asln was 57.63%, with the recovery of 98.09%.
结果超滤法能有效地将石杉堿甲固体脂质纳米粒与游离石杉堿甲分离,回收率为98.09%,测得3批样品的平均包封率为57.63%。
optimization of preparation and formulation was accomplished by evaluating the drug-loading amounts and the entrapment efficiency of luteolin liposomes.
方法采用薄膜分散法和冻干工艺进行木犀草素脂质体制备,并以载药量、包封率为评价指标,优化制备处方和工艺。