英语释义
1. a group of genes in mammals that code for cell-surface polymorphic glycoprotein molecules which display antigenic peptide fragments for T cell recognition and aid in the ability of the immune system to determine self from nonself Note: The genes of the major histocompatibility complex and the molecules they determine are grouped into 2 classes. Glycoprotein molecules of class I are expressed on all nucleated cells and are recognized by CD8 on the surface of cytotoxic T cells. Glycoprotein molecules of class II are restricted to antigen-presenting cells and are recognized by CD4 on the surface of helper T cells. —often used before another noun
major histocompatibility complex molecules —abbreviation MHC — compare HLA
2. a group of genes in mammals that function especially in determining the histocompatibility antigens found on cell surfaces and that in humans comprise the alleles occurring at four loci on the short arm of chromosome 6 Note: The genes of the major histocompatibility complex and the histocompatibility antigens they determine are grouped into 2 classes. Glycoprotein molecules of class I are expressed on all nucleated cells and are recognized by CD8 on the surface of cytotoxic T cells. Glycoprotein molecules of class II are restricted to antigen-presenting cells and are recognized by CD4 on the surface of helper T cells. —often used before another noun
major histocompatibility complex molecules —abbreviation MHC — compare HLA