英语释义

1. a numeral placed on a book to distinguish it from other copies of the same title

片语

copy-number variant变异

copy number variable regions拷贝数变异区域

copy-number dependent gene expression拷贝数依赖型基因表达

Low-copy-number数量分

high-copy-number高拷贝

copy number variation拷贝数变异

high-copy-number plasmid高拷贝质粒

copy number variations拷贝数变异

英汉例句

• the study evaluated the presence of substitutions, insertions, and deletions of 360 cancer genes in 413 invasive lobular breast cancer samples and copy number aberrations in 170 samples.

  此研究评价了413侵袭性乳腺小叶癌样本360个癌癥基因的替换、插入和缺失和170个样本复制数比率。

• microarrays are well suited for the integrative systems biology approach, but none of the existing microarray databases is focusing on copy number changes.

  微阵列非常适合于整合的系统生物学方式，但是没有一个现有的微阵列数据库是集中于拷贝数变化的。

• and in 2007 researchers sequenced the genome of genetic pioneer j. craig venter and found 62 copy number variations.

  而且，研究人员在2007年对遗传学的先驱克雷格·文特尔（j.craigventer ）的基因组测序发现有62个拷贝数变化。

• 「a genome-wide study reveals copy number variants exclusive to childhood obesity cases, 」 american journal of human genetics, published online oct. 14, 2010.

  《美国人类遗传学杂志》2010年10月14日在线发表：「一个揭示与儿童肥胖独特相关的基因拷贝数变异的研究」。

• 「the copy number variation that researchers had seen before was simply the tip of the iceberg, while the bulk lay submerged, undetected,」 said dr hurles.

  「研究人员以前看到的复制数量变化只是冰山一角，而其绝大部分都还未浮出水面，未被发现，」赫尔斯博士说。

• we determine the copy number oft -pa gene for the cell line.

  测定工程细胞株基因拷贝数是细胞生物学特性鑒定的一个方面。

• results it was shown that with the increase of age, copy number of homologous sequence decreases.

  结果随着小鼠年龄的增加，同源序列的拷贝数减少。

• defb gene products are small antimicrobial proinflammatory peptides, and copy number variation (cnv) could reasonably influence susceptibility to infection and inflammation.

  defb基因产物是小分子抗菌肽，且拷贝数变化（cnv）可显着影响易感性及炎癥反应。

• such surveys have revealed that large-scale cnvs are far more common than anyone expected - 65 to 80 percent of the population carries copy number variants affecting over 100,000 bases.

  调查显示，大型cnvs现象的普遍性超过任何人的预期——65%~80%的人类发生cnvs现象达到数百万bp范围。

• coincidentally, the psoriasis paper mentioned a recent study that linked sle to low copy number of complement c4 genes.

  巧合的是，银屑病论文提到近期一项研究将sle与补体蛋白c4基因拷贝数低联系起来。

• 「many examples of diseases resulting from changes in copy number are emerging,」 said charles lee, another project leader from harvard medical school in boston.

  「很多证据正在出现，表明疾病源自基因‘复制数量变异「，」另一个项目团队负责人、美国波士顿哈佛医学院(harvardmedicalschool)的查尔斯?李(charleslee)说。

• human epidermal growth factor receptor 2 testing in 2010: does chromosome 17 centromere copy number make any difference?

  2010年人表皮生长因子受体2检测：17号染色体着丝粒拷贝数是否具有影响？

• their study looked for chromosomal deletions and duplications known as copy number variants (cnv) and found that these were present in 16% of the children with adhd.

  他们研究被称为拷贝数变异（cnv）的染色体的删减和复制，发现在患有多动癥的儿童中有 16%都存在。

• intratumoral heterogeneity of egfr protein overexpression and egfr copy number alteration was not significant.

  egfr蛋白过表达和egfr拷贝数改变的肿瘤内异质性无统计学意义。

• users can build custom datasets by querying for specific clinical sample characteristics or copy number changes of individual genes.

  用户能够通过查询特定临床样品特征或个别基因的拷贝数变化构建定制的数据集。

• the experiment on the influence of the different repeat sequence on the copy number of plasmid is still under way.

  不同的重复序列对质粒拷贝数的影响实验正在进行中。

• the missing or extra bits of dna are called copy number variations (cnvs).

  丢失或存在多余dna的现象被称为拷贝数的变化（cnvs ）。

• after narrowing down the search to a short section on chromosome 17, the team looked for mutations called copy number variations, in which large chunks of dna are repeated or removed.

  研究小组将搜寻范围缩小到17号染色体的一小段上，然后寻找一种叫做「拷贝数变异」的基因突变现象。在拷贝数变异现象中，大块大块的dna存在重复或缺失。

• known as copy number variants (cnv), the genetic abnormalities are alterations within the chromosome which means a cell has an excess or an absence of a slice of dna.

  被称为拷贝数变异（cnv）的基因异常是染色体内部的改变。这意味着，一个细胞可能会多出或缺少一片dna。

• the effect of low copy number mutation on the stability of the recombinant plasmids was discussed.

  文中对质粒的稳定性与拷贝数的关系作了讨论。

• conclusion: met increased gene copy number is an independent negative prognostic factor in surgically resected nsclc. egfr gene gain does not impact survival after resection.

  结论：met增加的基因拷贝数增加是外科手术切除的nsclc的一个独立的负性预后因子。egfr基因获得对切除后病人没有影响。

• the data also showed that the integrate site, copy number of expression vectors, 5」 untranslated region and methanol utilization type had no obvious influence on yield of hsa.

  而载体整合方式、整合拷贝数、5’非翻译区的改造和甲醇利用表型等对表达量无规律性影响。

• methods comparative genomic hybridization(cgh)was used in screening dna copy number changes along all chromosomes in 23 cases of primary gastric cancer.

  方法采用比较基因组杂交分析23例原发性胃癌基因组dna拷贝数变化情况。

• the level of gfp gene expression showed significant difference among different transgenic cell lines integrated randomly, due to the difference of inserting loci and copy number of gfp gene.

  随机整合的转基因细胞系绿色荧光蛋白的表达水平有很大差异，主要与外源基因的拷贝数和插入位点有关。

• objective to establish a method for whole genome amplification (wga) based on (multiple displacement amplification mda), and achieve dna analysis of the human genome from low copy number (lcn).

  目的建立基于多重置换扩增（mda）技术的全基因组扩增（wga）方法，实现对低拷贝数（lcn）dna样品进行分析。

• all of the cght sufferers had a copy number variation in which dna was deleted across the same four genes, the authors report today in the american journal of human genetics.

  研究人员在今天出版的《美国人类遗传学杂志》上报道：所有的cght患者都存在拷贝数变异现象，在相同的四个基因里都存在dna缺失。