defb gene products are small antimicrobial proinflammatory peptides, and copy number variation (cnv) could reasonably influence susceptibility to infection and inflammation.
defb基因产物是小分子抗菌肽,且拷贝数变化(cnv)可显着影响易感性及炎癥反应。
「the copy number variation that researchers had seen before was simply the tip of the iceberg, while the bulk lay submerged, undetected,」 said dr hurles.
「研究人员以前看到的复制数量变化只是冰山一角,而其绝大部分都还未浮出水面,未被发现,」赫尔斯博士说。
all of the cght sufferers had a copy number variation in which dna was deleted across the same four genes, the authors report today in the american journal of human genetics.
研究人员在今天出版的《美国人类遗传学杂志》上报道:所有的cght患者都存在拷贝数变异现象,在相同的四个基因里都存在dna缺失。