objective to investigate the effect of jiawei sini powder on monoamine neurotransmitters in striatum of rat dysthymic disorder model.

目的观察加味四逆散对大鼠恶劣心境障碍模型纹状体单胺类神经递质的影响。

dysthymic disorder, or dysthymia , is characterized by long-term (2 years or longer) symptoms that may not be severe enough to disable a person but can prevent normal functioning or feeling well.

心境恶劣障碍 ，也叫做恶劣心境，以长期（两年或更长）但是较轻的癥状为特色。它并不一定使个人致残，但是能使个人正常机能受损或不能感到心情舒服。

hplc-ec was used to study the changes of monoamine transmitters in frontal lobe of rat dysthymic disorder model.

以hplc-ec法对照研究恶劣心境障碍大鼠额叶单胺类神经递质的改变。

objective: to investigate the effect of jiawei sini powder on monoamine transmitters in frontal lobe of rat dysthymic disorder model.

目的：观察加味四逆散对大鼠恶劣心境障碍模型额叶单胺类神经递质的影响。

objective: to investigate the effect of jiawei sini powder on monoamine transmitters in hippocampus of rat dysthymic disorder model.

目的：观察加味四逆散对大鼠恶劣心境障碍模型海马单胺类神经递质的影响。

there are several forms of depressive disorders. the most common are major depressive disorder and dysthymic disorder.

抑郁癥有几种类型。最常见的是重度抑郁癥和心境恶劣障碍。

the rat dysthymic disorder model was produced by separation and chronic unpredictable mild stress.

应用分养和长期不可预见性中等强度应激造成大鼠恶劣心境障碍模型。

hplc-ec was used to study the changes of monoamine transmitters in striatum of rat dysthymic disorder model.

以hplc-ec法对照研究恶劣心境障碍大鼠纹状体单胺类神经递质的改变。

dysthymic disorder, also called dysthymia.

心境恶劣障碍，也叫做恶劣心境。

conclusion: these data suggest that the monoamine transmitters in frontal lobe of rat dysthymic disorder model are decrease and jiawei sini powder was effective in the treatment of dysthymic disorder.

结论：结果提示恶劣心境障碍大鼠额叶单胺类神经递质含量降低，加味四逆散对恶劣心境障碍的治疗作用机理可能与改变额叶单胺能神经的功能状态有关。