these data are proof of principle for cell-type specific epigenetic regulation in placenta and demonstrate that the methylation profile of placenta is mainly driven by cytotrophoblasts.
这些数据是胚胎中细胞类型特异表观遗传调控原理的证明,并证明胚胎的甲基化谱主要由细胞滋养细胞驱动。
histone lysine methylation plays a key role in epigenetic regulation of eukaryotic genes.
组蛋白赖氨酸的甲基化在真核基因表观遗传调控中起着关键作用。
in the present paper we review the role and molecular mechanism of transcription factors, epigenetic regulation and cell signaling in cell reprogramming.
本文主要从转录因子、表观遗传和信号转导等角度,介绍了细胞重编程分子机制研究方面的进展和未来的方向。
these results extend the landscape of genetic alterations in leukaemia, and identify mutations targeting transcriptional and epigenetic regulation as a mechanism of resistance in all.
这些结果扩展了白血病的基因变异谱,确定后天调控与转录靶向突变为all的耐药机制。
using yeast as model organism, study the contribution of epigenetic regulation to the maintenance of genomic stability, by epigenetic, molecular genetic and biochemic approaches.