purpose:to research the association between homozygous deletion of p16 gene and primary epithelial ovarian neo-plasms.
目的:探讨p16基因的纯合性丢失和原发性上皮性卵巢癌发生及发展的相关性。
the rate of homozygous deletion of exon8 was 29.3%(12/41), and it was related to the tumor pathological grade, tnm stage and lymph node metastasis (p0.05).
methods: the homozygous deletion was detected by pcr-rflp in 106 chinese children with sma, gene conversion by rflp and subtle mutations by sequencing.