The absolute oral bioavailability of 9-NC was calculated to be 14.6%, which was consistent with the ratio of the total cumulative excretion in the urine and bile by ig to that by iv injection.
硝基喜树堿在大鼠体内的绝对生物利用度为14.6%,这与灌胃及静脉注射两种给药途径下原形药物(胆汁和尿中)累积排泄量之比值相一致。
Intestinal absorption enhancers are used to improve oral bioavailability of those compounds with poor membrane permeability.
吸收 促进剂可改善肠粘膜透过能力低药物的口服生物利用度。
Factors that affect the oral bioavailability of water insoluble drugs were discussed, and a review was given on the measures of improving the oral bioavailability of water insoluble drugs.
讨论了影响自胃肠道吸收药物生物利用度的因素,对提高难溶性药物口服生物利用度的方法进行了综述。
Many studies show that 4-oxo-dihydroquinolines have good oral bioavailability and plasma clearance, and they suppress both the DNA polymerase of HSV and virus replication in the cells.
多项研究表明,4 -氧代二氢喹啉类有良好的口服利用率及中等程度的血浆清除率,不仅对核苷酸聚合酶产生抑制,还可以抑制细胞内的病毒复制。
The enhancement of dissolution rate in vitro and oral bioavailability in vivo of poorly water-soluble drugs remains one of the most challenging aspects of modern pharmaceutics.
提高难溶性药物的体外溶出速度及其口服固体制剂的体内相对生物利用度,一直是现代药剂学研究领域中的热点和难点。
CONCLUSION: The insulin-liposomes double-coated with chitosan and CEC were in favor of improving oral bioavailability of insulin.
结论:壳聚糖-CEC双层包覆胰岛素脂质体有利于改善胰岛素口服生物利用度。