the overexpression of ligand-independent, constitutively active tshr abrogates osteoclast formation even under basal conditions and in the absence of tsh.
这种与配基无关的活性tshr的过度表达能阻止破骨细胞的形成,即使是在缺少tsh的情况下。
objective:to investigate the effect of the cyclic-tension force on the osteoclast formation in rat bone marrow culture, so as to learn about the mechanisms of bone remodeling under mechanical strain.
目的:通过大鼠骨髓破骨细胞的体外诱导培养,观察不同时段周期性牵张力对骨髓破骨细胞形成的影响。
tsh also suppresses osteoclast formation in murine macrophages and raw-c3 cells.
tsh还能抑制小鼠巨噬细胞和raw-c3细胞中破骨细胞的形成。
m-csf can induce human osteoclast formation and stimulate them to differentiate, survive and participate bone resorption caused by mature osteoclasts, and inhibit the apoptosis of osteoclasts.
csf可诱导人破骨细胞形成,刺激其分化、存活,参与成熟破骨细胞对骨的吸收作用;