methods the phase solubility diagram of cinnarizine-hpcd complex was obtained; the cinnarizine-hpcd complex was prepared and characterized by dsc method.
方法绘制桂利嗪hpcd包合物的相溶解度曲线,制备包合物并采用差示扫描量热法验证包合物的形成;
further more, the equilibrium-constant of the inclusion reaction was calculated by the data of phase solubility method.
包合后客体化合物的溶解度有了明显的提高,此外还用相溶解度法计算了包合反应的平衡常数。
results phase solubility diagram of cinnarizine-hpcd complex displayed a nonlinear curve.