英语释义

1. having a sequence complementary to a segment of genetic material specifically of, being, relating to, or possessing a sequence of DNA or RNA that is complementary to and pairs with a specific messenger RNA blocking it from being translated into protein and serving to inhibit gene function
antisense drug therapy antisense RNA — compare missense, nonsense

2. having a sequence complementary to a segment of genetic material specifically of, being, relating to, or possessing a sequence of DNA or RNA that is complementary to and pairs with a specific messenger RNA blocking it from being translated into protein and serving to inhibit gene function
antisense RNA antisense drug therapy to inhibit malignant cell proliferation antisense research — compare missense, nonsense

片语

antisense rna反义RNA

antisense drug反义药物

antisense messenger反义信使

antisense gene反义基因

Antisense Technology反义技术

antisense VEGF反义VEGF

antisense drugs反义药物

antisense sequence反义序列的

antisense oligodeoxynucleotide反义寡核苷酸

antisense DNA反义DNA

英汉例句

• the present report clearly shows how specific antisense biological activity can be achieved inside macrophages by means of three different delivery systems.

  本文对如何利用三种不同的运载系统在巨噬细胞内实现特定的反义生物活性进行了清晰的阐述。

• objective: to investigate the growth inhibition of antisense oligonucleotides of telomerase on liver tumor cell enhanced by albumin nanoparticles.

  目的：利用纳米载体增强端粒酶反义寡核苷酸对肝脏肿瘤细胞生长的抑制作用。

• such small antisense rnas may later have gained a role in rna editing, possibly under selective pressure to repair a region or restore a reading frame after loss or erosion of a module.

  之后，这些小的反义rna可能会在rna拼接中发挥作用，如在选择压力下修复基因组中一个区域，抑或在丧失或损坏一个模块后恢复一个读码框。

• in addition, the unique chemical, physical and biological properties of pnas have been exploited to produce powerful biomolecular tools, antisense and antigene agents, molecular probes and biosensors.

  此外，鑒于肽核酸独特的理化和生物学性能，人们正尝试将其用于生物分子工具、反义和反基因制剂、分子探针和生物传感器。

• objective to investigate the effect of il 12 antisense oligonucleotides on immunoglobulin secretion by pbmc from patients with active lupus nephritis (ln).

  目的探讨il12反义寡核苷酸对狼疮肾炎（ln）患者单个核细胞（pbmc）分泌免疫球蛋白的影响。

• interaction between fusion peptide of influenza virus a and its related antisense peptides was studied.

  据此初步结果，研究了甲型流感病毒融合肽与其反义肽的相互作用；

• antisense technology is a strategy of gene therapy.

  反义技术是基因治疗的一个策略。

• to our knowledge, this is the first evidence of in vitro pna antisense effect at nanomolar concentrations in phagocytic cells.

  从我们目前的了解看，此研究首次表明，在巨噬细胞中，肽核酸能在纳摩尔浓度水平发挥反义效果。

• the classical strategy for antisense therapy is to abrogate abnormal gene expression.

  反义治疗的经典策略是阻断异常基因的表达；

• both delivery through polymeric microspheres and encapsulation into erythrocytes allowed the antisense activity of unmodified pnas at nanomolar concentration.

  结果表明，将未修饰pna与聚合微球吸附或封装在自体红细胞，均可在纳摩尔浓度水平实现反义活性。

• objective to evaluate the therapeutic effect of antisense oligonucleotide targeting survivin in the treatment of tumor-bearing nude mice.

  目的评价生存素反义寡核苷酸在荷肝癌小鼠中的治疗作用。

• objective to study inhibition of vegf expression in human bladder carcinoma cells by antisense oligonucleotides.

  目的观察vegf反义寡核苷酸对膀胱癌细胞vegf表达的抑制情况。

• antisense morpholino oligos have shown promise in preclinical studies however, they were found to cause a limited viral load reduction.

  反义的吗啉寡展示了临诊前期的研究的前景，然而，它们被发现能引起一个有限的病毒载量减少。

• conclusion:eaac1 antisense oligonucleotide has the neuroprotective effect against acute cerebral ischemia injury.

  结论：eaac1反义寡核苷酸对急性脑缺血损伤有神经保护作用。

• objective to study the effects of antisense oligodeoxynucleotide(as/tf) for rat tissue factor (tf) on the myocardial ischemic reperfusion injury.

  目的：研究组织因子（tf）反义寡脱氧核苷酸（as/tf）对大鼠心肌缺血再灌注损伤的作用。

• antisense rna now being used in an attempt to provide an agent against bacteriophage genes to help in the constant struggle between lactic acid bacteria and their phages.

  现在正在使用反义rna技术试图提供一种抗噬菌体遗传因子的试剂，从而帮助乳酸菌和它们的噬菌体进行长期不问断的斗争。

• objective:to screen the high performance, specific and nontoxic anti hbv antisense oligonucleotide fragment.

  目的：筛选出高效特异而无毒的抗hbv反义寡核苷酸片段。

• objective:to study the antisense oligonucleotide mediated inhibition on telomerase activity and cell proliferation of gbc-sd cell.

  目的：探讨反义寡核苷酸对胆囊癌细胞端粒酶活性的影响及对胆囊癌细胞生长增殖的作用。

• the application of antisense technology in ophthalmology is introduced briefly in the review. this may be helpful to the studies in ophthalmic research field.

  本文对反义技术的概念及其在眼科领域中的应用作了简要介绍，以期对眼科领域的研究有所帮助。

• we discussed the right labeling method and conditions in order to lay the experiment foundation of the antisense medicament labeled by iodine for clinical application.

  力求找到最合适的标记方法、最恰当的标记条件。为今后碘标记的反义药物应用于临床奠定实验基础。

• conclusion gene gun transduction of k-ras antisense gene is a potential method for treatment of pancreatic carcinoma.

  结论突变特异性k-ras反义基因经基因枪有效转导后，可用于胰腺癌的治疗。

• objective to construct eukaryotic expression vector of antisense mbd1 gene fragment and to provide a tool for studying mbd1 gene function.

  目的构建反义mbd1基因片段真核表达载体，为研究mbd1基因功能提供工具。