something or someone that causes trouble; a source of unhappiness;

"washing dishes was a nuisance before we got a dish washer"

"a bit of a bother"

"he's not a friend, he's an infliction"

but barney frank, a congressman who has introduced legislation to repeal uigea, describes its enforcement mechanisms as 「a pain in the ass of the highest magnitude」.

但是议员barney frank已经提出立法废除uigea了，他将uigea的强制机制描述为「最严重的屁股疼」。

oh, that「s a pain in the ass to put that on.

噢，这是一个痛苦的驴子在此留下一个。

it」s simply a pain in the ass to distribute adhoc applications.

这只是为了发布adhoc应用的一个痛苦。

this is only a minor improvement, but it addresses a major pain in the ass in earlier versions of windows.

该进步虽小，解决的却是此前windows版本的一大积弊。

well, you「ve come this far, might as well stick it out. so the screening was a pain in the ass and they」re holding your money for the next six months, but hey, it's still a piece of cake.

好吧，你已经走到这个地步了，目前的状况是他们拿着你的钱，起码六个月之后之后才给你，不过，嘿，你还是挺占便宜的，不是么？

it’s a pain in the ass to find one, but there is some form of exercise that you will love.

寻找到一个你自己钟爱的锻炼方式是一个十分痛苦的过程。

no request can take more than 30 seconds to run, otherwise it is stopped: oh my god, this has been a pain in the ass all the time.

没有请求可以超过30秒，否则就被强制断掉。天啊，这是最痛苦的事了。