kinetics studies of protein polypeptide drugs face many challenges because of their low content in organisms, short half-life and vulnerability to interference by endogenous substances.
蛋白多肽类药物由于其在生物体内含量低、半衰期短和易受内源性物质干扰等特点而使其体内动力学的研究面临很多挑战。
the progress of the analysis of polypeptide drugs was reviewed, putting emphasis on bioactivity analysis, structure analysis and purity analysis.
介绍多肽药物的生物活性分析、结构分析、纯度分析的发展状况。
an obvious downside of enzyme and polypeptide drugs is lower bioavailability (
酶和多肽类药物口服生物利用度通常极低(<1%)。
at present, how to determine the polypeptide drugs in the biological matrix is a difficulty in the world which faces to a lot of challenges.
目前,建立测定生物基质中多肽类药物的方法学是世界范围存在的难题,面临着诸多挑战。