methods: using pcr sscp, we detected the mutation of insr tyrosine kinase domain exon 17 and exon 18 in 33 primary hypertension patients and 28 normal persons.
方法:对原发性高血压伴胰岛素抵抗患者胰岛素受体基因酪氨酸激酶域外显子17、18基因突变进行检测,并对突变的外显子进行核苷酸序列分析。
flt3 internal tandem duplication (itd) and tyrosine kinase domain (tkd) mutations are seen in 30% of aml patients (pts) and are associated with poor survival.
30%的急性髓系白血病(aml)患者发生flt3内部串联重复(itd)和酪氨酸激酶域(tkd)突变,而且生存预后较差。
gefitinib-sensitive mutations of the epidermal growth factor receptor tyrosine kinase domain in chinese patients with non-small cell lung cancer.
中国的非小细胞肺癌病人中吉非替尼敏感的表皮生长因子受体酪氨酸激酶区域的突变。
the first chapter is divided into four sections. the first section gave a detailed description of the structure of pkb's three major domains: ph domain, kinase domain and regulate domain.
第一章共分为四节:第一节介绍了pkb的结构特征,对其三大结构域:ph结构域、激酶结构域、调节结构域,进行了详细描述。
they found that the asymmetric activation of one egfr kinase domain by another is analogous to the activation of cyclin-dependent kinase (cdk) by cyclin, which are involved in regulating cell growth.
他们发现,由一个分子对另外一个egfr激酶结构域的不对称激活类似于涉及调控细胞生长的细胞周期蛋白激活细胞周期蛋白依赖型激酶的方式。
methods for treatment of cancer and reduction of tumor growth in individuals with secondary egfr mutations, particularly tyrosine kinase domain mutations, resistant to standard therapy are provided.
提供了用于在具有次级egfr突变,特别地酪氨酸激酶结构域突变的抗标準疗法的个体中治疗癌癥和减少肿瘤生长的方法。