as a delivery system for nasal immunization vaccines, biodegradable microspheres have several advantages such as extending immunization time and enhancing immune response.
可生物降解微球作为鼻腔免疫疫苗的载体有延长免疫时间、增强免疫作用等优点。
methods used to improve protein stability within biodegradable microspheres including microencapsulation process and formulation optimization are reviewed.
从微囊化工艺过程和微球处方因素两方面介绍近年缓释微球研发中改善蛋白活性的方法。
objective to study the pharmacokinetic characters of nitrendipine biodegradable microspheres and in situ forming gel.
目的研究尼群地平可生物降解微球和原位凝胶在家兔体内的药物动力学特征。
conclusions comparing with nitrendipine solution, nitrendipine biodegradable microspheres and in situ forming gel had longer action time in rabbits, but their relative bioavailabilities were lower.
结论尼群地平可生物降解微球和原位凝胶与尼群地平溶液相比,在家兔体内具有更长的作用时间,但相对生物利用度较低。
although the controlled release system based on biodegradable microspheres has made great progress. the application of this formulation in clinical is still very limited.
尽管可降解聚合物微球在药物控释领域的应用已经取得了一定的进展,然而真正用于临床的微球制剂并不多。