aim: to study the buccal adhesive tablets of felodipine and to abserve its swelling rate, adhesive force and drug release rate.
目的:研制非洛地平口腔粘附片,考察其体外膨胀率、粘附力及释药性能。
conclusion the adhesive property of the tablets and the release behavior of drug are relevant. also, the formulation of buccal adhesive tablets is optimized by adjusting the composition.
结论口颊黏附片的生物黏附性与体外释药行为具有一定的相关性,通过调整处方可筛选出生物黏附性和体外释药均较理想的处方。
results:the buccal adhesive tablets of tetracaine prepared by cp and hpc(or hpmc)with 12 produced effect within 1~2min. the adhesive time in oral cavity was more than 3h, and above 10h at night.
结果:用cp与hpc(或hpmc)以12的比率制备的丁卡因口腔粘附片在1~2分钟内起效,口腔内的粘附时间大于3小时,夜间使用可达10小时以上。
conclusion:the good effect can be obtained on the buccal adhesive tablets when using cp and hpc(or hpmc)as the adhesive materials.
结论:cp与hpc(或hpmc)作为粘附材料制备丁卡因口腔粘附片能获得良好效果。